CAIRO, Dec 11 (Aswat Masriya) - At least 25 were killed in an explosion in the vicinity of the Coptic Orthodox Cathedral of Abbasiya on Sunday morning, state-run television reported.
A security source told Aswat Masriya that 56 others were injured in the explosion.
According to Egypt's state television the blast took place in the Botroseya Church building, which is situated next to the Cathedral.
Females constitute the bigger number of victims as the explosion happened near the section designed for female worshipers, according to MENA news agency.
So far, no group has claimed responsibility for the attack.
Injured were transferred to Dar El-Shefaa and Al-Demerdash hospitals for treatment, according to state television.
Security forces closed off the road and combed the area in search of other explosive devices.
Egypt's Prosecutor General has ordered the Supreme State Security Prosecution to investigate the attack.
This comes two days after six security personnel were killed and three others were injured in an explosion in Haram district in Giza. Recently-emerged movement calling itself "Hasam" claimed responsibility for the explosion.
Militants have stepped up attacks targeting security forces in Egypt, since the ouster of Islamist President Mohamed Mursi in July 2013 after mass protests against his rule.